Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17514790 | 0.86 | CYP1A1 (0.41) | PGRARKMT2AGAACYP11B1 | |
| SCHEMBL17536769 | 0.83 | KDM4E (0.44) | ARKMT2AMAOBALDH1A1MAPT | |
| SCHEMBL3829054 | 0.80 | KIF11 (0.45) | MAOBALDH1A1 | |
| SCHEMBL2433532 | 0.80 | NR1H2 (0.35) | PGRARKMT2AGAACYP11B2 | |
| SCHEMBL1369135 | 0.79 | KIF11 (0.39) | GAACYP11B2ALDH1A1LMNAACHE | |
| SCHEMBL6513958 | 0.78 | ACHE (0.35) | KMT2AGAAALDH1A1MAPTMEN1 | |
| SCHEMBL8125843 | 0.77 | KMT2A (0.40) | PGRARKMT2AGAAMAOB | |
| SCHEMBL8089529 | 0.76 | CA12 (0.41) | ALDH1A1ACHETP53NPC1RAB9A | |
| SCHEMBL1867724 | 0.76 | ABL1 (0.50) | KMT2AMAPTLMNATP53NPC1 | |
| SCHEMBL6188780 | 0.76 | CA12 (0.41) | KMT2AALDH1A1MAPTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313156-B1 | FOR THERAPY OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES AND PROINFLAMMATORY MEDIATORS | ICOS CORPORATION | 2001-11-06 | — | — | US | disclosed |