Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.31 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955157 | 0.93 | AVPR2 (0.36) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7474244 | 0.91 | AVPR2 (0.33) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7963072 | 0.87 | ADRA1D (0.33) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7479769 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL7954101 | 0.84 | DRD2 (0.34) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7475346 | 0.84 | MAP3K7 (0.32) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7953703 | 0.84 | AVPR2 (0.39) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7478471 | 0.81 | MAP3K7 (0.36) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7971950 | 0.81 | AVPR2 (0.41) | ADRA1DADRA1AADRA1BAVPR2AVPR1A | |
| SCHEMBL7967019 | 0.81 | CPT1A (0.34) | ADRA1DADRA1AADRA1BAVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |