Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 3/20 | 0.41 |
| ▸ | PTPRC | P08575 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27508603 | 1.00 | KMT2A (0.43) | KMT2AGAAHSD17B10PRSS1CTSG | |
| SCHEMBL6981775 | 1.00 | KMT2A (0.43) | KMT2AGAAHSD17B10PRSS1CTSG | |
| SCHEMBL7955112 | 0.89 | MAPT (0.40) | KMT2AGAAHSD17B10PRSS1CTSG | |
| SCHEMBL7836648 | 0.89 | MAPT (0.40) | KMT2AGAAHSD17B10PRSS1CTSG | |
| SCHEMBL6980588 | 0.88 | NPC1 (0.48) | KMT2APRSS1CTSGCTRB1CMA1 | |
| SCHEMBL6980590 | 0.88 | NPC1 (0.48) | KMT2APRSS1CTSGCTRB1CMA1 | |
| SCHEMBL2322450 | 0.85 | NPC1 (0.49) | KMT2AGAAHSD17B10PRSS1CTSG | |
| SCHEMBL7957323 | 0.83 | CTSK (0.53) | CTSLCTSKCTSBCTSS | |
| SCHEMBL6945114 | 0.81 | ADAM17 (0.37) | KMT2AGAAHSD17B10PRSS1CTSG | |
| SCHEMBL27471453 | 0.78 | ACE (0.47) | MAPTNPSR1POLBMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |