Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | ITGAV | P06756 | 3/20 | 0.37 |
| ▸ | PTPRC | P08575 | 2/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6941639 | 0.87 | MAPT (0.37) | ADAM17PSMB5CTSLCTSKCTSB | |
| SCHEMBL6939576 | 0.85 | ADAM17 (0.40) | ADAM17PSMB5MAPTKMT2AMEN1 | |
| SCHEMBL6940214 | 0.85 | ADAM17 (0.48) | ADAM17ITGAVCTSLCTSKCTSB | |
| SCHEMBL6942897 | 0.81 | ADAM17 (0.40) | ADAM17KMT2AHPGDMEN1 | |
| SCHEMBL7955112 | 0.81 | MAPT (0.40) | ADAM17PTPRCCTSLCTSKCTSB | |
| SCHEMBL7836648 | 0.81 | MAPT (0.40) | ADAM17PTPRCCTSLCTSKCTSB | |
| SCHEMBL6981775 | 0.81 | KMT2A (0.43) | ADAM17ITGAVPTPRCCTSLCTSK | |
| SCHEMBL27508603 | 0.81 | KMT2A (0.43) | ADAM17ITGAVPTPRCCTSLCTSK | |
| SCHEMBL7955175 | 0.81 | KMT2A (0.43) | ADAM17ITGAVPTPRCCTSLCTSK | |
| SCHEMBL6947989 | 0.80 | MMP1 (0.46) | ADAM17PSMB5KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |