Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 16/20 | 0.42 |
| ▸ | MMP1 | P03956 | 16/20 | 0.42 |
| ▸ | MMP9 | P14780 | 16/20 | 0.41 |
| ▸ | MMP7 | P09237 | 7/20 | 0.41 |
| ▸ | MMP13 | P45452 | 6/20 | 0.41 |
| ▸ | MMP2 | P08253 | 4/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077049 | 1.00 | ALDH1A1 (0.44) | ALDH1A1LMNACA12CA1CA2 | |
| SCHEMBL6076217 | 0.88 | CA12 (0.41) | CA12CA1CA2CA9MMP3 | |
| SCHEMBL6076042 | 0.85 | CA12 (0.53) | ALDH1A1LMNACA12CA1CA2 | |
| SCHEMBL6075691 | 0.83 | MMP3 (0.49) | CA12CA1CA2CA9MMP3 | |
| SCHEMBL6075492 | 0.81 | MMP1 (0.45) | CA12CA1CA2CA9MMP3 | |
| SCHEMBL7389317 | 0.81 | CA12 (0.50) | LMNACA12CA1CA2CA9 | |
| SCHEMBL6075812 | 0.81 | CA12 (0.48) | ALDH1A1LMNACA12CA1CA2 | |
| SCHEMBL6076126 | 0.80 | MMP3 (0.47) | MMP3MMP1MMP9MMP7MMP13 | |
| SCHEMBL6075406 | 0.80 | MMP3 (0.46) | LMNAMMP3MMP1MMP9MMP7 | |
| SCHEMBL6076087 | 0.79 | CA12 (0.47) | CA12CA1CA2CA9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291450-B1 | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use | AMGEN INC. | 2001-09-18 | — | — | US | disclosed |