Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241881 | 0.81 | BCHE (0.45) | L3MBTL1HRH4NR1H4MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3880186 | 0.80 | BCHE (0.44) | L3MBTL1HRH4NR1H4MEN1KMT2A | |
| SCHEMBL7966522 | 0.76 | CYP3A4 (0.44) | SLC6A4HTR3ARAB9ANOS1GABRA1 | |
| SCHEMBL10834084 | 0.76 | HRH4 (0.46) | L3MBTL1HRH4ABL1NR1H4MEN1 | |
| SCHEMBL7955026 | 0.75 | MEN1 (0.42) | HRH4EP300NR1H4MEN1KMT2A | |
| SCHEMBL7967300 | 0.72 | TLR9 (0.43) | L3MBTL1HRH4SLC6A2SLC6A4GABRA1 | |
| SCHEMBL13592675 | 0.72 | EP300 (0.43) | HRH4EP300MEN1KMT2AUSP7 | |
| SCHEMBL30468937 | 0.70 | HTR1A (0.40) | HRH4MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL24218862 | 0.68 | GSK3B (0.64) | — | |
| SCHEMBL18319496 | 0.68 | DYRK1A (0.51) | IKBKBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |