Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965539 | 0.78 | ALDH1A1 (0.46) | CYP3A4ALDH1A1HTR3EHTR3BCYP1A2 | |
| SCHEMBL7955491 | 0.76 | L3MBTL1 (0.40) | SLC6A4HTR3ANOS1GABRA1RAB9A | |
| SCHEMBL5241881 | 0.75 | BCHE (0.45) | CYP1A2SLC6A4HTR3AGABRA1 | |
| Hydrochloric Acid SCHEMBL3880186 | 0.74 | BCHE (0.44) | CYP1A2SLC6A4HTR3AGABRA1 | |
| SCHEMBL10834084 | 0.71 | HRH4 (0.46) | CYP1A2SLC6A4HTR3AGABRA1 | |
| SCHEMBL31703587 | 0.70 | RAB9A (0.61) | CYP3A4ALDH1A1HTR3EHTR3BCYP1A2 | |
| SCHEMBL7970187 | 0.69 | ALDH1A1 (0.56) | CYP3A4ALDH1A1CYP1A2MAPTLMNA | |
| SCHEMBL7970193 | 0.69 | ALDH1A1 (0.48) | CYP3A4ALDH1A1HTR3EHTR3BCYP1A2 | |
| SCHEMBL7955486 | 0.69 | BCHE (0.57) | CYP3A4ALDH1A1HTR3EHTR3BCYP1A2 | |
| SCHEMBL17374976 | 0.69 | MAPT (0.46) | CYP3A4ALDH1A1CYP1A2MAPTNOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |