Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954797 | 0.79 | TLR9 (0.44) | TLR9TLR8TLR7SLC6A2SLC6A4 | |
| SCHEMBL5241881 | 0.77 | BCHE (0.45) | SLC6A2SLC6A4SLC6A3L3MBTL1HRH4 | |
| Hydrochloric Acid SCHEMBL3880186 | 0.76 | BCHE (0.44) | SLC6A2SLC6A4SLC6A3L3MBTL1HRH4 | |
| SCHEMBL24218862 | 0.73 | GSK3B (0.64) | GSK3BDYRK1A | |
| SCHEMBL7955491 | 0.72 | L3MBTL1 (0.40) | TLR9TLR8TLR7SLC6A2SLC6A4 | |
| SCHEMBL10834084 | 0.72 | HRH4 (0.46) | SLC6A2SLC6A4L3MBTL1HRH4GABRA1 | |
| SCHEMBL10262259 | 0.69 | CYP1A2 (0.53) | — | |
| SCHEMBL10199297 | 0.69 | GRM4 (0.42) | — | |
| SCHEMBL7971282 | 0.69 | RAB9A (0.64) | TLR9TLR8TLR7SLC6A2SLC6A4 | |
| SCHEMBL18319496 | 0.68 | DYRK1A (0.51) | GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |