Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656587 | 0.92 | PTGS2 (0.46) | PTGS2BCL9CTNNB1ALDH1A1HPSE | |
| SCHEMBL7957336 | 0.92 | PTGS2 (0.46) | PTGS2BCL9CTNNB1ALDH1A1HPSE | |
| SCHEMBL7958643 | 0.81 | LGALS8 (0.45) | PTGS2ALDH1A1 | |
| SCHEMBL8316403 | 0.81 | LGALS8 (0.45) | PTGS2ALDH1A1 | |
| SCHEMBL9053183 | 0.79 | CA12 (0.48) | BCL9CTNNB1LMNAALDH1A1KDM4E | |
| SCHEMBL7596584 | 0.79 | CA12 (0.48) | BCL9CTNNB1LMNAALDH1A1KDM4E | |
| SCHEMBL2296345 | 0.79 | CA12 (0.48) | BCL9CTNNB1LMNAALDH1A1KDM4E | |
| SCHEMBL2943984 | 0.79 | CA12 (0.48) | BCL9CTNNB1LMNAALDH1A1KDM4E | |
| SCHEMBL15782553 | 0.79 | CA12 (0.48) | BCL9CTNNB1LMNAALDH1A1KDM4E | |
| SCHEMBL4609138 | 0.79 | CA12 (0.48) | BCL9CTNNB1LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271342-B1 | SERUM STABILITY; FOR TUMOR THERAPY | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-07 | — | — | US | disclosed |
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |