Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957336 | 1.00 | PTGS2 (0.46) | PTGS2BCL9CTNNB1ALDH1A1HPSE | |
| SCHEMBL7955558 | 0.92 | PTGS2 (0.46) | PTGS2BCL9CTNNB1ALDH1A1HPSE | |
| SCHEMBL8316403 | 0.88 | LGALS8 (0.45) | PTGS2ALDH1A1 | |
| SCHEMBL7958643 | 0.88 | LGALS8 (0.45) | PTGS2ALDH1A1 | |
| SCHEMBL7957577 | 0.84 | ALDH1A1 (0.39) | BCL9CTNNB1ALDH1A1HPSEKDM4E | |
| SCHEMBL7655962 | 0.84 | CA12 (0.35) | ALDH1A1 | |
| SCHEMBL6817377 | 0.84 | CA12 (0.37) | BCL9CTNNB1ALDH1A1HPSEKDM4E | |
| SCHEMBL7948150 | 0.80 | NT5E (0.38) | PTGS2ALDH1A1HPSE | |
| SCHEMBL15782553 | 0.79 | CA12 (0.48) | BCL9CTNNB1ALDH1A1KDM4E | |
| SCHEMBL2296345 | 0.79 | CA12 (0.48) | BCL9CTNNB1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492335-B1 | Glycoconjugates from modified camptothecin derivatives (20-O-linkage) | BAYER AKTIENGESELLSCHAFT (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-0934329-B1 | GLYCOCONJUGATES FROM MODIFIED CAMPTOTHECIN DERIVATES (20-O-LINKAGE) | BAYER AG (DE) | 2001-12-12 | — | — | EP | disclosed |
| EP-0939765-B1 | GLYCOCONJUGATES OF MODIFIED CAMPTOTHECIN DERIVATIVES (A- OR B-RING LINKAGE) | BAYER AG (DE) | 2001-12-05 | — | — | EP | disclosed |
| US-6271342-B1 | SERUM STABILITY; FOR TUMOR THERAPY | BAYER AKTIENGESELLSCHAFT (DE) | 2001-08-07 | — | — | US | disclosed |
| US-6156754-A | Glycoconjugates of modified camptothecin derivatives (A-or B-ring linkage) | BAYER AKTIENGESELLSCHAFT (DE) | 2000-12-05 | — | — | US | disclosed |
| EP-0819135-B1 | SUGAR-MODIFIED CYTOSTATICS | BAYER AG (DE) | 1999-11-17 | — | — | EP | disclosed |