Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975270 | 0.90 | CA12 (0.42) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL7968918 | 0.86 | RAB9A (0.54) | RAB9ASMN1; SMN2L3MBTL1KMT2ANPC1 | |
| SCHEMBL7975277 | 0.85 | RAB9A (0.55) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL7967861 | 0.85 | RAB9A (0.51) | RAB9ASMN1; SMN2L3MBTL1KMT2ANPC1 | |
| SCHEMBL7967421 | 0.84 | KMT2A (0.54) | RAB9ASMN1; SMN2L3MBTL1KMT2ANPC1 | |
| SCHEMBL7966143 | 0.84 | HTT (0.53) | RAB9ASMN1; SMN2L3MBTL1KMT2ANPC1 | |
| SCHEMBL7977635 | 0.83 | CA12 (0.51) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL7970330 | 0.83 | RAB9A (0.64) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL7968264 | 0.82 | KMT2A (0.56) | CA12CA1CA2CA9RAB9A | |
| SCHEMBL7974448 | 0.82 | BDKRB1 (0.44) | RAB9ASMN1; SMN2L3MBTL1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |