Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.55 |
| ▸ | NPC1 | O15118 | 10/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.55 |
| ▸ | RELA | Q04206 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA9 | Q16790 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968918 | 0.88 | RAB9A (0.54) | RAB9ANPC1SMN1; SMN2HTTMAPT | |
| SCHEMBL7971214 | 0.87 | SMN1; SMN2 (0.46) | RAB9ANPC1SMN1; SMN2HTTMAPT | |
| SCHEMBL7967861 | 0.87 | RAB9A (0.51) | RAB9ANPC1SMN1; SMN2HTTMAPT | |
| SCHEMBL7972214 | 0.86 | MAPT (0.44) | RAB9ANPC1SMN1; SMN2HTTMAPT | |
| SCHEMBL7972711 | 0.86 | RAB9A (0.53) | RAB9ANPC1SMN1; SMN2MAPTPKM | |
| SCHEMBL7966143 | 0.86 | HTT (0.53) | RAB9ANPC1SMN1; SMN2HTTMAPT | |
| SCHEMBL7967421 | 0.86 | KMT2A (0.54) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL7977635 | 0.85 | CA12 (0.51) | RAB9ANPC1SMN1; SMN2MAPTPOLB | |
| SCHEMBL7955588 | 0.85 | CA12 (0.53) | RAB9ANPC1SMN1; SMN2HTTMAPT | |
| SCHEMBL7970330 | 0.85 | RAB9A (0.64) | RAB9ANPC1SMN1; SMN2MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |