Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.54 |
| ▸ | MEN1 | O00255 | 11/20 | 0.54 |
| ▸ | MAPT | P10636 | 12/20 | 0.53 |
| ▸ | RAB9A | P51151 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971048 | 0.89 | RAB9A (0.42) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7968918 | 0.87 | RAB9A (0.54) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7967861 | 0.86 | RAB9A (0.51) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7975277 | 0.86 | RAB9A (0.55) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7966143 | 0.85 | HTT (0.53) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7970330 | 0.84 | RAB9A (0.64) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7955588 | 0.84 | CA12 (0.53) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7977635 | 0.84 | CA12 (0.51) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7974448 | 0.83 | BDKRB1 (0.44) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL7974449 | 0.83 | KDM4E (0.54) | KMT2AMAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |