Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454952 | 0.92 | TSHR (0.50) | TSHRHTTLMNAALDH1A1MAPT | |
| SCHEMBL14141438 | 0.85 | TSHR (0.54) | TSHRHTTLMNAALDH1A1MAPT | |
| SCHEMBL264567 | 0.85 | TSHR (0.48) | TSHRHTTLMNAALDH1A1KMT2A | |
| SCHEMBL19463301 | 0.83 | TSHR (0.47) | TSHRHTTLMNAALDH1A1KMT2A | |
| SCHEMBL905407 | 0.83 | TSHR (0.47) | TSHRHTTLMNAALDH1A1KMT2A | |
| SCHEMBL277616 | 0.83 | ALDH1A1 (0.33) | TSHRHTTLMNAALDH1A1KMT2A | |
| SCHEMBL29044559 | 0.83 | TSHR (0.47) | TSHRHTTLMNAALDH1A1KMT2A | |
| SCHEMBL19696384 | 0.83 | TSHR (0.41) | TSHRHTTLMNAALDH1A1MAPT | |
| SCHEMBL25818843 | 0.83 | ALDH1A1 (0.32) | ALDH1A1KMT2ASMN1; SMN2PSMB8PSMB5 | |
| SCHEMBL43576 | 0.82 | PSMB8 (0.35) | TSHRLMNAKMT2ASMN1; SMN2PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316669-B1 | OPHTHALMOLOGY | ALCON MANUFACTURING, LTD. | 2001-11-13 | — | — | US | disclosed |