Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416131 | 0.97 | HTR1A (0.79) | HTR1A | |
| Hydrochloric Acid SCHEMBL4426960 | 0.96 | HTR1A (0.77) | HTR1A | |
| SCHEMBL8544143 | 0.91 | HTR1A (0.73) | HTR1A | |
| SCHEMBL7530566 | 0.91 | HTR1A (0.76) | HTR1A | |
| SCHEMBL9696788 | 0.91 | HTR1A (0.79) | HTR1A | |
| SCHEMBL8542180 | 0.90 | HTR1A (0.78) | HTR1A | |
| Hydrochloric Acid SCHEMBL7954846 | 0.90 | HTR1A (0.75) | HTR1A | |
| SCHEMBL8539433 | 0.88 | HTR1A (0.72) | HTR1A | |
| SCHEMBL8537885 | 0.88 | ADRA2A (0.80) | HTR1A | |
| SCHEMBL16855092 | 0.88 | HTR1A (1.00) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736525-A1 | Benzonitriles and -fluorides as 5-HT agonists and antagonists | MERCK PATENT GmbH (DE) | 1996-10-09 | — | — | EP | claimed |
| US-6310068-B1 | 3-(4-(4-(4-CYANOPHENYL)-1-PIPERAZINYL)BUTYL)-5-CYANOINDOLE; 3-(4-(4-(4-FLUOROPHENYL)-1-PIPERAZINYL)BUTYL)-5-CYANOINDOLE, BOTH IN FORM OF HYDROCHLORIDE SALT; TREATING DEPRESSION, PARKINSON'S DISEASE, ISCHEMIA | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2001-10-30 | — | — | US | disclosed |
| EP-0736525-A1 | Benzonitriles and -fluorides as 5-HT agonists and antagonists | MERCK PATENT GmbH (DE) | 1996-10-09 | — | — | EP | disclosed |