Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | ACHE | P22303 | 1/20 | 0.66 |
| ▸ | RAD52 | P43351 | 1/20 | 0.66 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827360 | 0.98 | HRH3 (0.75) | HRH3KCNH2ACHERAD52HRH1 | |
| SCHEMBL1986761 | 0.91 | PSMB1 (0.67) | HRH3 | |
| SCHEMBL1986256 | 0.89 | PSMB1 (0.70) | HRH3 | |
| SCHEMBL4416554 | 0.89 | PSMB1 (0.70) | HRH3 | |
| SCHEMBL3581930 | 0.89 | HRH3 (0.89) | HRH3KCNH2ACHERAD52HRH1 | |
| SCHEMBL7945866 | 0.86 | RAB9A (0.66) | HRH3KCNH2MEN1KMT2A | |
| SCHEMBL12050718 | 0.85 | HRH3 (0.96) | HRH3KCNH2HRH1 | |
| SCHEMBL3578646 | 0.85 | HRH3 (0.90) | HRH3KCNH2ACHERAD52HRH1 | |
| SCHEMBL2819860 | 0.85 | HRH3 (0.77) | HRH3KCNH2ACHERAD52 | |
| SCHEMBL4094339 | 0.84 | HRH3 (1.00) | HRH3KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297274-B1 | SUBSTITUTED 5-HYDROXYFURANONES | WARNER-LAMBERT COMPANY | 2001-10-02 | — | — | US | claimed |
| WO-1997037985-A1 | NONPEPTIDE ENDOTHELIN ANTAGONISTS WITH INCREASED WATER SOLUBILITY | WARNER-LAMBERT COMPANY (US) | 1997-10-16 | — | — | WO | claimed |
| US-6297274-B1 | SUBSTITUTED 5-HYDROXYFURANONES | WARNER-LAMBERT COMPANY | 2001-10-02 | — | — | US | disclosed |
| WO-1997037985-A1 | NONPEPTIDE ENDOTHELIN ANTAGONISTS WITH INCREASED WATER SOLUBILITY | WARNER-LAMBERT COMPANY (US) | 1997-10-16 | — | — | WO | disclosed |