Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | LIPE | Q05469 | 8/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961398 | 0.83 | LIPG (0.57) | LIPGHRH3LIPEACACBHSD11B1 | |
| SCHEMBL7947575 | 0.83 | LIPG (0.57) | LIPGHRH3LIPEHSD11B1SCD | |
| SCHEMBL7956670 | 0.78 | LIPG (0.52) | LIPGHRH3LIPESCDRET | |
| SCHEMBL26620366 | 0.78 | LIPG (0.62) | LIPGHRH3LIPEACACBHSD11B1 | |
| SCHEMBL29995167 | 0.78 | LIPG (0.62) | LIPGHRH3LIPEACACBHSD11B1 | |
| SCHEMBL23702994 | 0.78 | LIPG (0.62) | LIPGHRH3LIPEACACBHSD11B1 | |
| SCHEMBL29994537 | 0.78 | LIPG (0.62) | LIPGHRH3LIPEACACBHSD11B1 | |
| SCHEMBL23702850 | 0.78 | LIPG (0.62) | LIPGHRH3LIPEACACBHSD11B1 | |
| SCHEMBL7954969 | 0.78 | LIPG (0.53) | LIPGHRH3LIPESCDRET | |
| SCHEMBL7956252 | 0.77 | LIPG (0.60) | LIPGHRH3LIPEHSD11B1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |