Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | LIPE | Q05469 | 6/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7956252 | 0.85 | LIPG (0.60) | LIPGHRH3LIPEHSD11B1CYP3A4 | |
| SCHEMBL7961497 | 0.85 | LIPG (0.60) | LIPGHRH3LIPEHSD11B1CYP3A4 | |
| SCHEMBL7956524 | 0.85 | LIPG (0.60) | LIPGHRH3LIPEHSD11B1CYP3A4 | |
| SCHEMBL7956574 | 0.83 | LIPG (0.57) | LIPGHRH3LIPEHSD11B1SCD | |
| SCHEMBL7947501 | 0.81 | LIPG (0.61) | LIPGHRH3LIPEHSD11B1SCD | |
| SCHEMBL7961541 | 0.80 | LIPG (0.53) | LIPGHRH3LIPEHSD11B1CYP3A4 | |
| SCHEMBL425198 | 0.76 | HRH3 (0.56) | LIPGHRH3CYP3A4KDM4EABL1 | |
| SCHEMBL29240878 | 0.76 | LIPG (0.57) | LIPGHRH3LIPEHSD11B1SCD | |
| SCHEMBL7961398 | 0.76 | LIPG (0.57) | LIPGHRH3LIPEHSD11B1SCD | |
| SCHEMBL29240882 | 0.76 | LIPG (0.57) | LIPGHRH3LIPEHSD11B1SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |