Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 15/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074829 | 0.82 | ELANE (0.49) | ELANEAPLNRMAPTKMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL7075284 | 0.81 | ELANE (0.48) | ELANEAPLNRMAPTKMT2ACYP1A2 | |
| SCHEMBL27158525 | 0.75 | PTPN1 (0.46) | ELANEAPLNRMAPTKMT2ATNKS | |
| SCHEMBL7071124 | 0.74 | ELANE (0.54) | ELANEMAPT | |
| SCHEMBL19805539 | 0.70 | CA1 (0.43) | ELANEAPLNRMAPTKMT2ACYP1A2 | |
| SCHEMBL7199762 | 0.67 | ELANE (0.71) | ELANE | |
| Hydrochloric Acid SCHEMBL7117389 | 0.64 | ELANE (0.35) | ELANEAPLNRCYP1A2CYP2D6 | |
| SCHEMBL16997506 | 0.64 | ALDH1A1 (0.41) | ELANEAPLNRKMT2ATNKSPARP1 | |
| SCHEMBL15599598 | 0.63 | ALDH1A1 (0.39) | ELANEAPLNRTNKSPARP1PARP2 | |
| SCHEMBL14803532 | 0.61 | ECE1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255453-B1 | INHIBITORS OF HUMAN NEUTOPHIL ELASTASE; TREATMENT OF ADULT RESPIRATORY DISTRESS SYNDROME, SEPTIC SHOCK, MULTIPLE ORGAN FAILURE, PERIODONTAL DISEASE, GLOMERULONEPHRITIS, CYSTIC FIBROSIS; ANTIARTHRTITIC AGENTS | CORTECH, INC. | 2001-07-03 | — | — | US | disclosed |