Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 14/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958318 | 0.94 | PTGIR (0.43) | PTGIRADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL7958975 | 0.88 | KDM4E (0.46) | PTGIRADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL7956256 | 0.85 | PTGIR (0.45) | PTGIRADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL7948818 | 0.83 | KDM4E (0.45) | PTGIRADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL7956031 | 0.83 | F2RL3 (0.43) | ADORA2AADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL7958495 | 0.78 | PTGIR (0.59) | PTGIRKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL7958324 | 0.73 | ADORA3 (0.43) | PTGIRADORA2AADORA3ADORA1KDM4E | |
| SCHEMBL7948871 | 0.71 | PTGIR (0.61) | PTGIRKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL7956320 | 0.71 | NPC1 (0.47) | ADORA2AKDM4EALDH1A1HPGDADORA2B | |
| SCHEMBL7959182 | 0.69 | ADORA3 (0.41) | ADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |