Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.78 |
| ▸ | TDP2 | O95551 | 1/20 | 0.78 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.78 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 9/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.69 |
| ▸ | ATM | Q13315 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | CCR6 | P51684 | 1/20 | 0.69 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.69 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.69 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MITF | O75030 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955400 | 0.88 | TDP2 (1.00) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL10891344 | 0.85 | HKDC1 (0.70) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL6239428 | 0.84 | HKDC1 (0.68) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL8108611 | 0.82 | MAPT (0.61) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL8108449 | 0.82 | MAPT (0.65) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL6190569 | 0.81 | HSP90AA1 (1.00) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL31087717 | 0.81 | HSP90AA1 (1.00) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL8671274 | 0.81 | MAPT (0.59) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL11217803 | 0.79 | MAPT (0.74) | HKDC1TDP2PAX8TLR9MAPT | |
| SCHEMBL8102171 | 0.79 | MAPT (0.62) | HKDC1TDP2PAX8TLR9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174918-B1 | INHIBITING TUMOR CELL GROWTH SENSITIVE TO NAPHTHOQUINONE DERIVATIVE IN MAMMAL BY ADMINISTERING 2,3-DISUBSTITUTED NAPHTHOQUINONE COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2001-01-16 | — | — | US | disclosed |
| US-5789431-A | INHIBITING CELL TUMOR GROWTH | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-08-04 | — | — | US | disclosed |
| WO-1997030022-A1 | NAPHTHOQUINONE ANTITUMOR COMPOUND AND METHOD | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-08-21 | — | — | WO | disclosed |
| US-4628062-A | 1,4-naphthoquinone derivatives having anti-inflammatory action | TROPONWERKE GMBH & CO., KG (DE) | 1986-12-09 | — | — | US | disclosed |