Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM6 | O15303 | 12/20 | 0.77 |
| ▸ | GRM5 | P41594 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 6/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | GAA | P10253 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CASP1 | P29466 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099130 | 0.88 | GRM6 (0.74) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL27461391 | 0.88 | GRM6 (0.60) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL1929543 | 0.85 | GRM6 (0.70) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL7207512 | 0.84 | GRM6 (0.71) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL10714368 | 0.84 | GRM6 (1.00) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL14699088 | 0.84 | ALDH1A1 (0.64) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL27461392 | 0.82 | GRM6 (0.54) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL4217459 | 0.82 | GRM6 (1.00) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL26637734 | 0.81 | GRM6 (0.52) | GRM6GRM5ALDH1A1HPGDMAPT | |
| SCHEMBL10713203 | 0.79 | ALDH1A1 (0.71) | GRM6GRM5ALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794616-A1 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013057253-A1 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-25 | — | — | WO | disclosed |
| CN-1173977-C | Process for preparing thienopyrimidine derivatives | 武田药品工业株式会社 | 2004-11-03 | — | — | CN | disclosed |
| CN-1539836-A | Processes for prodn. of thienopyrimidine derivatives | 武田药品工业株式会社 | 2004-10-27 | — | — | CN | disclosed |
| CN-1406239-A | Process for preparing thienopyrimidine derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-26 | — | — | CN | disclosed |
| US-6313301-B1 | CYCLIZATION; LUTEINIZING HORMONE RELEASING HORMONE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-11-06 | — | — | US | disclosed |
| CN-1063446-C | Thienopyridine derivatives as gonadotropin releasing hormone antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-03-21 | — | — | CN | disclosed |
| US-6015789-A | LUTEINIZING HORMONE RELEASING HORMONE AGONIST AND A LUTEINIZING HORMONE RELEASING HORMONE ANTAGONIST IN COMBINATION, | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-01-18 | — | — | US | disclosed |
| US-5977132-A | GALACTORRHEA, HYPERPROLACTINEMIC OVULATION, PROLACTINOMA AND BRAIN TUMORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0906115-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 1999-04-07 | — | — | EP | disclosed |
| CN-1200124-A | Thienopyridine derivatives as gonadotropin releasing hormone antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-11-25 | — | — | CN | disclosed |
| EP-0862573-A1 | THIENOPYRIDINE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | Takeda Chemical Industries, Ltd. (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5744479-A | PITUITARY HORMONE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-28 | — | — | US | disclosed |
| CN-1175258-A | Thienoxazinone derivatives useful as antiviral agents | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |
| WO-1997040846-A1 | COMBINED USE OF GnRH AGONIST AND ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-11-06 | — | — | WO | disclosed |
| EP-0781774-A2 | Prolactin production inhibitory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-02 | — | — | EP | disclosed |
| WO-1997014697-A1 | THIENOPYRIDINE DERIVATIVES AS GONADOTROPIN RELEASING HORMONE ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |
| CN-1106663-A | Thienopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-08-16 | — | — | CN | disclosed |
| US-4692461-A | PLANT PROTECTION | BAYER AKTIENGESELLSCHAFT (DE) | 1987-09-08 | — | — | US | disclosed |