Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.47 |
| ▸ | ACE | P12821 | 9/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.47 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.44 |
| ▸ | PSAT1 | Q9Y617 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837561 | 1.00 | MME (0.47) | MMEACEACE2CPA1CTSS | |
| SCHEMBL6940090 | 0.92 | ACE (0.47) | MMEACEPOLBMAPTATM | |
| SCHEMBL27471453 | 0.92 | ACE (0.47) | MMEACEPOLBMAPTATM | |
| SCHEMBL7840436 | 0.87 | CTSS (0.47) | MMEACEACE2CPA1CTSS | |
| SCHEMBL7946604 | 0.87 | CTSS (0.47) | MMEACEACE2CPA1CTSS | |
| SCHEMBL15015724 | 0.82 | SLC1A3 (0.51) | ACECPA1CTSSCTSKSRR | |
| SCHEMBL7280316 | 0.82 | SLC1A3 (0.51) | ACECPA1CTSSCTSKSRR | |
| SCHEMBL7764145 | 0.82 | CASP3 (0.45) | POLBMMP1 | |
| SCHEMBL7764153 | 0.82 | CASP3 (0.45) | POLBMMP1 | |
| SCHEMBL7759196 | 0.81 | POLB (0.49) | ACE2CTSKPOLBMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |