Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 4/20 | 0.46 |
| ▸ | ACE | P12821 | 3/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.46 |
| ▸ | CPA1 | P15085 | 2/20 | 0.46 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | FCER2 | P06734 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840436 | 1.00 | CTSS (0.47) | CTSSCTSKMMEACEACE2 | |
| SCHEMBL7837561 | 0.87 | MME (0.47) | CTSSCTSKMMEACEACE2 | |
| SCHEMBL7957368 | 0.87 | MME (0.47) | CTSSCTSKMMEACEACE2 | |
| SCHEMBL7960522 | 0.85 | KMT2A (0.41) | MMEACEACE2CPA1REN | |
| SCHEMBL7839117 | 0.85 | KMT2A (0.41) | MMEACEACE2CPA1REN | |
| SCHEMBL7827850 | 0.80 | MMP1 (0.46) | CTSSCTSKRENPOLBMAPT | |
| SCHEMBL7853167 | 0.80 | MMP1 (0.46) | CTSSCTSKRENPOLBMAPT | |
| SCHEMBL7836454 | 0.80 | MMP1 (0.46) | CTSSCTSKRENPOLBMAPT | |
| SCHEMBL7853162 | 0.80 | MMP1 (0.46) | CTSSCTSKRENPOLBMAPT | |
| SCHEMBL27471453 | 0.80 | ACE (0.47) | MMEACERENPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |