Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | DRD3 | P35462 | 3/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959549 | 0.90 | DRD2 (0.47) | DRD2DRD4DRD3MCHR1LMNA | |
| SCHEMBL7949172 | 0.90 | DRD2 (0.61) | DRD2DRD4DRD3MCHR1 | |
| SCHEMBL10595036 | 0.90 | SLC18A3 (0.61) | DRD2ADRA1DADRA1AADRA1BSLC18A3 | |
| SCHEMBL7960719 | 0.89 | DRD2 (0.62) | DRD2DRD4DRD3 | |
| SCHEMBL7959172 | 0.83 | DRD2 (0.62) | DRD2DRD4DRD3SLC18A3HTR4 | |
| SCHEMBL17107369 | 0.83 | HTR4 (0.45) | DRD2DRD4DRD3LMNASLC18A3 | |
| SCHEMBL17107412 | 0.83 | HTR4 (0.45) | DRD2DRD4DRD3LMNASLC18A3 | |
| SCHEMBL15740658 | 0.83 | HTR4 (0.45) | DRD2DRD4DRD3LMNASLC18A3 | |
| SCHEMBL13723201 | 0.82 | SLC18A3 (0.48) | DRD2DRD4DRD3LMNASLC18A3 | |
| SCHEMBL6994781 | 0.82 | DRD2 (0.53) | DRD2DRD3MCHR1SLC18A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |