Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | PRCP | P42785 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957439 | 0.90 | DRD2 (0.55) | DRD2DRD4DRD3SLC18A3HTR4 | |
| SCHEMBL7949172 | 0.88 | DRD2 (0.61) | DRD2DRD4DRD3MCHR1 | |
| SCHEMBL10595036 | 0.88 | SLC18A3 (0.61) | DRD2PRCPSLC18A3KMT2AHTR4 | |
| SCHEMBL7960719 | 0.87 | DRD2 (0.62) | DRD2DRD4DRD3HRH2HRH1 | |
| SCHEMBL7959172 | 0.81 | DRD2 (0.62) | DRD2DRD4DRD3SLC18A3HRH1 | |
| SCHEMBL17107412 | 0.81 | HTR4 (0.45) | DRD2DRD4DRD3SLC18A3HTR4 | |
| SCHEMBL15740658 | 0.81 | HTR4 (0.45) | DRD2DRD4DRD3SLC18A3HTR4 | |
| SCHEMBL17107369 | 0.81 | HTR4 (0.45) | DRD2DRD4DRD3SLC18A3HTR4 | |
| SCHEMBL13723201 | 0.80 | SLC18A3 (0.48) | DRD2PRCPDRD4DRD3SLC18A3 | |
| SCHEMBL6994781 | 0.80 | DRD2 (0.53) | DRD2PRCPDRD3SLC18A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |