Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418615 | 0.89 | KCNK3 (0.45) | HDAC3HDAC7HDAC9HDAC5NCOR2 | |
| SCHEMBL7964544 | 0.87 | KMT2A (0.42) | HDAC3HDAC7HDAC9HDAC5NCOR2 | |
| SCHEMBL7419611 | 0.86 | USP2 (0.39) | HDAC3HDAC7HDAC9HDAC5NCOR2 | |
| SCHEMBL7961855 | 0.82 | SMN1; SMN2 (0.55) | ALDH1A1KDM4EHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL7957484 | 0.82 | POLB (0.45) | POLBKCNK3KCNK9 | |
| SCHEMBL7964125 | 0.81 | NTRK1 (0.43) | ALDH1A1KDM4EHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL7964346 | 0.81 | KMT2A (0.41) | ALDH1A1KDM4EHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL7959624 | 0.80 | NPC1 (0.48) | ALDH1A1KDM4EHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL7964564 | 0.80 | USP2 (0.51) | ALDH1A1HPGDKMT2ASMN1; SMN2POLB | |
| SCHEMBL7958034 | 0.79 | MEN1 (0.44) | ALDH1A1KDM4EHPGDKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218384-B1 | FOR THERAPY OF ANXIETY, MUSCLE SPASMS, SLEEPLESSNESS, CONVULSIONS AND BENZODIAZEPINE OVERDOSES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-04-17 | — | — | US | disclosed |
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | disclosed |