Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.55 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25676227 | 0.85 | HDAC3 (0.59) | NAAAHDAC3HDAC8MAPTMAPK1 | |
| SCHEMBL3634350 | 0.83 | NAAA (0.87) | NAAAHDAC3MAPTNAMPT | |
| SCHEMBL25676224 | 0.83 | HDAC3 (0.56) | NAAAHDAC3HDAC8MAPTMAPK1 | |
| SCHEMBL7402710 | 0.83 | DRD2 (0.59) | DRD2 | |
| SCHEMBL7501490 | 0.82 | DRD2 (0.56) | DRD2CHRNA10CHRNA9 | |
| SCHEMBL6301416 | 0.81 | SMYD3 (0.54) | NAAAHDAC3HDAC8MAPTMAPK1 | |
| Water SCHEMBL5211069 | 0.80 | SMYD3 (0.53) | NAAAHDAC3HDAC8MAPTMAPK1 | |
| SCHEMBL7961490 | 0.79 | MAPT (0.54) | DRD2MAPT | |
| Hydrochloric Acid SCHEMBL6139757 | 0.79 | SMYD3 (0.52) | NAAAHDAC3HDAC8MAPTMAPK1 | |
| SCHEMBL2355678 | 0.79 | DRD3 (0.72) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |