SCHEMBL6301416

SCHEMBL6301416

CCCCNC(=O)c1ccc(N2CCC(N)CC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMYD3 Q9H7B4 1/20 0.54
HDAC3 O15379 6/20 0.54
HDAC8 Q9BY41 5/20 0.54
CHRNA10 Q9GZZ6 1/20 0.54
CHRNA9 Q9UGM1 1/20 0.54
MAPT P10636 1/20 0.52
MAPK1 P28482 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.48
POLB P06746 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CYP1A2 P05177 1/20 0.47
HPGD P15428 2/20 0.46
ALDH1A1 P00352 1/20 0.46
TP53 P04637 1/20 0.46
CA2 P00918 1/20 0.46
NAAA Q02083 1/20 0.46
HDAC1 Q13547 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL5211069 0.99 SMYD3 (0.53) SMYD3HDAC3HDAC8CHRNA10CHRNA9
Hydrochloric Acid SCHEMBL6139757 0.97 SMYD3 (0.52) SMYD3HDAC3HDAC8CHRNA10CHRNA9
SCHEMBL25676227 0.84 HDAC3 (0.59) HDAC3HDAC8CHRNA10CHRNA9MAPT
SCHEMBL25676224 0.82 HDAC3 (0.56) HDAC3HDAC8CHRNA10CHRNA9MAPT
SCHEMBL7958146 0.81 NAAA (0.62) HDAC3HDAC8CHRNA10CHRNA9MAPT
SCHEMBL3293622 0.79 ALDH1A1 (0.54) HDAC3MAPTL3MBTL1SMN1; SMN2HPGD
SCHEMBL3293618 0.79 ALDH1A1 (0.54) HDAC3MAPTL3MBTL1SMN1; SMN2HPGD
SCHEMBL5208027 0.79 PDE5A (0.46) SMYD3HDAC3HDAC8CHRNA10CHRNA9
SCHEMBL28326194 0.77 L3MBTL1 (0.73) MAPTMAPK1L3MBTL1SMN1; SMN2ALDH1A1
SCHEMBL27474182 0.76 NAAA (0.50) HDAC3HDAC8CHRNA10CHRNA9MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6858629-B1 Heteroaryloxy propanolamines, preparation method and pharmaceutical compositions containing same SANOFI-SYNTHELABO (FR) 2005-02-22 US disclosed
EP-1214313-B1 HETEROARYLOXY PROPANOLAMINES, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME SANOFI SYNTHELABO (FR) 2004-06-30 EP disclosed