Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7962718 | 0.88 | HTR2C (0.49) | HTR2CP2RX7HTR6MCL1BAD | |
| SCHEMBL7960415 | 0.83 | HTR2C (0.51) | HTR2C | |
| SCHEMBL7958387 | 0.80 | HTR2C (0.51) | HTR2CHTR6MCL1BADMEN1 | |
| SCHEMBL7958447 | 0.80 | MCL1 (0.54) | HTR6MCL1BADMEN1KMT2A | |
| SCHEMBL7959061 | 0.80 | HTR2C (0.54) | HTR2CP2RX7HTR6MCL1BAD | |
| SCHEMBL7958451 | 0.78 | HTR2C (0.49) | HTR2CHTR6MCL1BADMEN1 | |
| SCHEMBL2038502 | 0.76 | HTR2C (0.63) | HTR2CHTR6 | |
| SCHEMBL3245076 | 0.72 | HTR2C (0.66) | HTR2CHTR6CDK4CCND1 | |
| SCHEMBL28760998 | 0.71 | HTR2C (0.57) | HTR2CHTR6MCL1BADKMT2A | |
| SCHEMBL4652431 | 0.70 | HTR2C (0.69) | HTR2CHTR6CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |