Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958387 | 0.92 | HTR2C (0.51) | HTR2CHRH3KLKB1KLK1MEN1 | |
| SCHEMBL7960113 | 0.84 | HTR2C (0.54) | HTR2CKLKB1KLK1HTR6MCL1 | |
| SCHEMBL7962451 | 0.81 | HTR6 (0.47) | HRH3KLKB1KLK1HTR6MCL1 | |
| SCHEMBL7958296 | 0.80 | MCL1 (0.56) | HTR6MCL1BAD | |
| SCHEMBL7962718 | 0.80 | HTR2C (0.49) | HTR2CMEN1KMT2AHTR6MCL1 | |
| SCHEMBL7958314 | 0.78 | HTR2C (0.50) | HTR2CMEN1KMT2AHTR6MCL1 | |
| SCHEMBL2038502 | 0.75 | HTR2C (0.63) | HTR2CHTR6 | |
| SCHEMBL8616920 | 0.74 | HTR6 (0.60) | HTR2CMEN1KMT2AHTR6 | |
| SCHEMBL7948387 | 0.72 | MCL1 (0.55) | HTR6MCL1BAD | |
| SCHEMBL3245076 | 0.71 | HTR2C (0.66) | HTR2CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1092639-C | Benzene-fused heterocyclic derivative and use thereof | TORAY INDUSTRIES (JP) | 2002-10-16 | — | — | CN | disclosed |
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| CN-1148381-A | Benzene-fused heterocyclic derivative and use thereof | TORAY INDUSTRIES (JP) | 1997-04-23 | — | — | CN | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |