SCHEMBL7958414

SCHEMBL7958414

Cc1cc(CC(=O)O)oc1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.47
TTR P02766 1/20 0.42
APEX1 P27695 2/20 0.41
ALOX15 P16050 1/20 0.40
HPGD P15428 2/20 0.39
RAB9A P51151 2/20 0.39
GLA P06280 1/20 0.39
NPC1 O15118 1/20 0.39
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
KDM4E B2RXH2 1/20 0.38
TSHR P16473 1/20 0.38
AGBL2 Q5U5Z8 2/20 0.37
HSD17B10 Q99714 2/20 0.37
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
POLB P06746 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
KDM4C Q9H3R0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2030407 0.83 NPSR1 (0.39) PTGER4TTRAPEX1HPGDRAB9A
SCHEMBL7960304 0.81 APEX1 (0.38) PTGER4TTRAPEX1ALOX15HPGD
SCHEMBL14200101 0.79 PTGER4 (0.54) PTGER4TTRAPEX1ALOX15HPGD
SCHEMBL7960299 0.79 APEX1 (0.36) PTGER4TTRAPEX1HPGDRAB9A
SCHEMBL9768897 0.78 TAS1R3 (0.35) TTRAPEX1HPGDRAB9AGLA
SCHEMBL27629893 0.77 PTGER4 (0.52) PTGER4TTRAPEX1ALOX15HPGD
SCHEMBL17895745 0.76 EPHX2 (0.46) PTGER4ALDH1A1SMN1; SMN2TSHRNPSR1
SCHEMBL4301123 0.73
SCHEMBL5898325 0.73
SCHEMBL1915243 0.71 POLB (0.38) TTRAPEX1HPGDRAB9AGLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6184245-B1 Cyclic ketone derivatives and their medical applications TORAY INDUSTRIES INC. (JP) 2001-02-06 US disclosed
EP-0962456-A1 CYCLIC KETONE DERIVATIVE AND PHARMACEUTICAL USE THEREOF TORAY INDUSTRIES, INC. (JP) 1999-12-08 EP disclosed