Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 6/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957015 | 0.80 | ACACB (0.41) | PDE3BPDE3APDE10AACACB | |
| SCHEMBL7947301 | 0.80 | ACACB (0.41) | PDE3BPDE3APDE10AACACB | |
| SCHEMBL7961553 | 0.80 | ACACB (0.41) | PDE3BPDE3APDE10AACACB | |
| SCHEMBL30349356 | 0.76 | MET (0.48) | PDE3BPDE3APDE10APIK3CDPIK3CA | |
| SCHEMBL2621757 | 0.76 | MET (0.48) | PDE3BPDE3APDE10APIK3CDPIK3CA | |
| SCHEMBL7956861 | 0.75 | ACACB (0.51) | PDE3BPDE3APDE10AACACB | |
| SCHEMBL7958355 | 0.73 | HRH3 (0.42) | ACACB | |
| SCHEMBL7956626 | 0.72 | HCRTR2 (0.48) | PDE10A | |
| SCHEMBL7958453 | 0.71 | HRH3 (0.44) | PDE3BPDE3APDE10AACACB | |
| SCHEMBL5632542 | 0.71 | ACACB (0.43) | PDE3BPDE3APDE10AACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |