Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961553 | 0.92 | ACACB (0.41) | HRH3LSSDGAT1ACACBOXTR | |
| SCHEMBL7957015 | 0.92 | ACACB (0.41) | HRH3LSSDGAT1ACACBOXTR | |
| SCHEMBL7947301 | 0.92 | ACACB (0.41) | HRH3LSSDGAT1ACACBOXTR | |
| SCHEMBL7956692 | 0.84 | FPR2 (0.47) | HRH3CHKAF10 | |
| SCHEMBL7956483 | 0.84 | HRH3 (0.44) | HRH3CHKAACACBOXTRAVPR1A | |
| SCHEMBL7956260 | 0.81 | DPP4 (0.47) | HRH3F10ADRB2NCF1PLD1 | |
| SCHEMBL7961541 | 0.81 | LIPG (0.53) | HRH3 | |
| SCHEMBL15633157 | 0.79 | DGAT1 (0.49) | HRH3DGAT1ACACBAVPR1AHCRTR1 | |
| SCHEMBL7961706 | 0.79 | MAPT (0.46) | HRH3F10 | |
| SCHEMBL3617804 | 0.79 | TDO2 (0.49) | HRH3DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |