Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.38 |
| ▸ | PTGIR | P43119 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957984 | 0.81 | TBXA2R (0.32) | ALDH1A1TBXA2RPTGIRMAOAMAPT | |
| SCHEMBL11740786 | 0.69 | KDM4E (0.49) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL4138721 | 0.68 | MEN1 (0.43) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL12330749 | 0.68 | ALDH1A1 (0.54) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL20064626 | 0.66 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL11637652 | 0.66 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL7948373 | 0.65 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL30937511 | 0.65 | ALOX15 (0.54) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL27984738 | 0.65 | ALOX15 (0.54) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL1126000 | 0.65 | CA1 (0.44) | ALDH1A1MEN1KMT2AKIF11CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |