Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6178255 | 0.87 | HTR1A (0.45) | HTR1ACCR5MEN1KMT2APTGDR2 | |
| SCHEMBL27573266 | 0.86 | HTR1A (0.45) | HTR1ASIGMAR1CCR5CTSDACKR3 | |
| SCHEMBL7955962 | 0.84 | HTR1A (0.42) | HTR1ACCR5MEN1KMT2APTGDR2 | |
| SCHEMBL6176757 | 0.77 | KMT2A (0.48) | SIGMAR1CCR3MEN1KMT2ACHRM4 | |
| SCHEMBL27509799 | 0.76 | KMT2A (0.47) | SIGMAR1MEN1KMT2ACHRM4 | |
| SCHEMBL6176762 | 0.76 | MEN1 (0.51) | MEN1KMT2ACHRM4 | |
| SCHEMBL7968954 | 0.75 | HTR1A (0.42) | HTR1ACCR3MEN1KMT2AACKR3 | |
| Cyclohexane SCHEMBL6180435 | 0.75 | MEN1 (0.48) | HTR1AMEN1KMT2ACHRM4 | |
| SCHEMBL6177497 | 0.74 | MEN1 (0.51) | MEN1KMT2A | |
| Cyclohexane SCHEMBL6178387 | 0.73 | MEN1 (0.48) | HTR1AMEN1KMT2ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239126-B1 | ANTAGONISTS OF THE 5HT1A RECEPTOR SUBTYPE. | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-29 | — | — | US | claimed |
| US-6239126-B1 | ANTAGONISTS OF THE 5HT1A RECEPTOR SUBTYPE. | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-29 | — | — | US | disclosed |