Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958707 | 0.87 | HTR1A (0.43) | HTR1AKMT2AMEN1PTGDR2OPRD1 | |
| SCHEMBL7955962 | 0.85 | HTR1A (0.42) | HTR1AKMT2AMEN1PTGDR2OPRD1 | |
| Cyclohexane SCHEMBL6180435 | 0.81 | MEN1 (0.48) | HTR1AKMT2AMEN1CHRM4MAPK1 | |
| Cyclohexane SCHEMBL6178387 | 0.79 | MEN1 (0.48) | HTR1AKMT2AMEN1CHRM4MAPK1 | |
| SCHEMBL6176757 | 0.78 | KMT2A (0.48) | KMT2AMEN1CHRM4MAPK1 | |
| SCHEMBL27509799 | 0.77 | KMT2A (0.47) | KMT2AMEN1CHRM4MAPK1 | |
| SCHEMBL6177497 | 0.75 | MEN1 (0.51) | KMT2AMEN1MAPK1 | |
| SCHEMBL6176762 | 0.75 | MEN1 (0.51) | KMT2AMEN1CHRM4MAPK1 | |
| SCHEMBL6176194 | 0.75 | MEN1 (0.52) | HTR1AKMT2AMEN1CHRM4MAPK1 | |
| SCHEMBL6177728 | 0.74 | HTR1A (0.56) | HTR1AKMT2AMEN1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140830-B1 | ARYLPIPERIDINE AND ARYL-1,2,5,6-TETRAHYDROPYRIDINE AMIDE DERIVATIVES HAVING 5HT1A RECEPTOR ACTIVITY | WYETH CORP (US) | 2005-05-04 | — | — | EP | claimed |