Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 4/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372034 | 0.81 | HSD11B1 (0.54) | KDM4EALDH1A1GRIN2BCARM1PRMT6 | |
| SCHEMBL7974993 | 0.80 | LMNA (0.60) | CCR3KDM4ESMN1; SMN2LMNAMAPK1 | |
| SCHEMBL29501461 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1ATMGRIN2BMEN1 | |
| Hydrochloric Acid SCHEMBL7968770 | 0.79 | LMNA (0.59) | CCR3KDM4ESMN1; SMN2LMNAMAPK1 | |
| SCHEMBL2958775 | 0.77 | KDM4E (0.47) | CCR3KDM4ESMN1; SMN2ALDH1A1ATM | |
| SCHEMBL2004615 | 0.76 | CCR3 (1.00) | CCR3KDM4EALDH1A1ATMGLA | |
| SCHEMBL10374099 | 0.76 | HTR2A (0.51) | CCR3LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL10372369 | 0.76 | MEN1 (0.58) | MAPTMEN1KMT2A | |
| SCHEMBL10373204 | 0.76 | HSD11B1 (0.46) | SMN1; SMN2LMNAMAPTHTTL3MBTL1 | |
| SCHEMBL7977320 | 0.75 | CCR3 (0.96) | CCR3KDM4EALDH1A1ATMGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281359-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2001-08-28 | — | — | US | disclosed |
| US-6221871-B1 | TREATING SCHIZOPHRENIA, DEPRESSION OR PARKINSON'S DISEASE | NEUROGEN CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-5594141-A | ANTIPSYCHOTIC AND ANTIDEPRESSANT AGENTS; PARKINSON'S DISEASE | NEUROGEN CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |