Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.51 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116506 | 0.87 | HTT (0.56) | HTTKAT6AKMT2ABCL2MMP2 | |
| SCHEMBL7975877 | 0.83 | HDAC8 (0.63) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7971329 | 0.83 | HDAC8 (0.58) | HDAC8HTTALDH1A1BCL2 | |
| SCHEMBL7969746 | 0.82 | HDAC8 (0.66) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7976180 | 0.76 | GAA (0.57) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL21422370 | 0.74 | HDAC8 (0.81) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7973319 | 0.74 | HDAC8 (0.58) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7971489 | 0.74 | MMP2 (0.59) | HDAC8HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL3562537 | 0.73 | HDAC8 (0.61) | HDAC8HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12694145 | 0.73 | HDAC8 (0.61) | HDAC8HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271247-B1 | BINDING TO NEUROPEPTIDE RECEPTORS | ADIR ET COMPAGNIE (FR) | 2001-08-07 | — | — | US | disclosed |
| US-6172108-B1 | NEUROPEPTIDE Y RECEPTOR LIGANDS; TREATING PSYCHOLOGICAL, EATING, SLEEP, AND SEXUAL DISORDERS; HYPOTENSIVE, ANXIOLYTIC, ANTIDEPRESSANT, AND ANTIDIABETIC AGENTS | ADIR ET COMPAGNIE (FR) | 2001-01-09 | — | — | US | disclosed |
| EP-1010691-A2 | Hydrazide derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-06-21 | — | — | EP | disclosed |