Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852753 | 0.86 | TDP1 (0.49) | TDP1L3MBTL1TSHRALDH1A1CA2 | |
| SCHEMBL7946512 | 0.85 | NAPRT (0.48) | TDP1L3MBTL1TSHRALDH1A1CA2 | |
| SCHEMBL7957115 | 0.85 | SMN1; SMN2 (0.48) | TDP1L3MBTL1TSHRALDH1A1CA2 | |
| SCHEMBL7954849 | 0.84 | POLB (0.51) | TSHRALDH1A1HCRTR2POLBSMN1; SMN2 | |
| SCHEMBL17600704 | 0.81 | LMNA (0.53) | HCRTR1HCRTR2POLBRAB9A | |
| SCHEMBL17600705 | 0.81 | LMNA (0.53) | HCRTR1HCRTR2POLBRAB9A | |
| SCHEMBL5909267 | 0.80 | KMT2A (0.53) | TDP1TSHRALDH1A1CA2HCRTR1 | |
| SCHEMBL6265889 | 0.79 | HSD11B1 (0.56) | — | |
| SCHEMBL20858858 | 0.78 | ITGB1 (0.67) | L3MBTL1ALDH1A1CA2ITGB3ITGB1 | |
| SCHEMBL3175587 | 0.77 | DGAT1 (0.54) | TDP1L3MBTL1TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194426-B1 | CONTROLLING TUMOR NECROSIS FACTOR | RHONA-POULENC RORER S.A. (FR) | 2001-02-27 | — | — | US | disclosed |
| WO-1998025612-A1 | NOVEL THERAPEUTIC APPLICATION OF PYRROLE DERIVATIVES | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | disclosed |