Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.54 |
| ▸ | DRD4 | P21917 | 6/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7959536 | 0.78 | SIGMAR1 (0.52) | HTR1ADRD4DRD3KDM4EGAA | |
| SCHEMBL7960090 | 0.77 | HTR1A (0.54) | HTR1ADRD4DRD3DRD2HTR2A | |
| SCHEMBL7960945 | 0.73 | HTR1A (0.55) | HTR1ADRD4DRD3KDM4EGAA | |
| SCHEMBL7960085 | 0.70 | MAPT (0.45) | DRD4DRD2 | |
| SCHEMBL14440419 | 0.69 | HTR1A (0.61) | HTR1ADRD4DRD3KDM4EGAA | |
| SCHEMBL6598139 | 0.69 | HTR1A (1.00) | HTR1ADRD4DRD3DRD2 | |
| SCHEMBL5776291 | 0.68 | SIGMAR1 (0.51) | HTR1ADRD4DRD3KDM4EGAA | |
| SCHEMBL7957403 | 0.68 | MAPT (0.46) | HTR1ADRD3KDM4EDRD2HTR2A | |
| SCHEMBL7957648 | 0.67 | SIGMAR1 (0.52) | HTR1ADRD4DRD3KDM4EGAA | |
| SCHEMBL7959986 | 0.67 | HTR1A (0.51) | HTR1ADRD4DRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |