Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 14/20 | 0.51 |
| ▸ | DRD3 | P35462 | 12/20 | 0.51 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | HTR2A | P28223 | 8/20 | 0.51 |
| ▸ | HRH1 | P35367 | 5/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.51 |
| ▸ | DRD1 | P21728 | 5/20 | 0.49 |
| ▸ | DRD5 | P21918 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957403 | 0.89 | MAPT (0.46) | SIGMAR1KDM4EDRD2DRD3HTR1A | |
| SCHEMBL7959986 | 0.88 | HTR1A (0.51) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7959137 | 0.88 | SIGMAR1 (0.53) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL5776291 | 0.81 | SIGMAR1 (0.51) | SIGMAR1KDM4EGAADRD2DRD3 | |
| SCHEMBL7957648 | 0.79 | SIGMAR1 (0.52) | SIGMAR1KDM4EGAADRD2DRD3 | |
| Fumaric Acid SCHEMBL7959573 | 0.78 | SIGMAR1 (0.49) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| Maleic Acid SCHEMBL7959572 | 0.78 | SIGMAR1 (0.49) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7960186 | 0.78 | HTR1A (0.54) | SIGMAR1KDM4EGAADRD2DRD3 | |
| SCHEMBL7960090 | 0.78 | HTR1A (0.54) | SIGMAR1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL7963930 | 0.76 | SIGMAR1 (0.53) | SIGMAR1DRD2DRD3HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | claimed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |