Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973155 | 0.90 | F9 (0.39) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7972135 | 0.89 | PDE10A (0.37) | NPC1RAB9ADGAT1KCNH2SMN1; SMN2 | |
| SCHEMBL7970581 | 0.89 | F9 (0.40) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10140044 | 0.89 | HSD17B1 (0.37) | KCNH2ATRMAPTTDO2 | |
| SCHEMBL10140046 | 0.88 | KDM4E (0.43) | NPC1RAB9ADGAT1KCNH2ALDH1A1 | |
| SCHEMBL10140038 | 0.88 | KIT (0.37) | NPC1RAB9ADGAT1SOAT1KCNH2 | |
| SCHEMBL7971397 | 0.88 | ALDH1A1 (0.39) | NPC1RAB9APKMALDH1A1HPGD | |
| SCHEMBL7960814 | 0.88 | NPC1 (0.39) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7970587 | 0.88 | TOP1 (0.34) | DGAT1SOAT1KCNH2ALDH1A1HPGD | |
| SCHEMBL7970061 | 0.88 | GUSB (0.39) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |