Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7563176 | 0.92 | LMNA (0.61) | SLC22A1ADRB2ADRB1LMNAHIF1A | |
| SCHEMBL13039940 | 0.81 | LMNA (0.66) | SLC22A1ADRB2ADRB1LMNAHIF1A | |
| SCHEMBL3884423 | 0.80 | ALDH1A1 (0.58) | LMNAKDM4EMAPTHSD17B10NPSR1 | |
| SCHEMBL19445590 | 0.79 | HDAC3 (0.54) | SLC22A1ADRB2ADRB1LMNAHIF1A | |
| SCHEMBL21852785 | 0.79 | NPC1 (0.64) | MTNR1BMAPTNPSR1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL25217998 | 0.78 | ALDH1A1 (0.56) | LMNAKDM4EMAPTHSD17B10NPSR1 | |
| Hydrochloric Acid SCHEMBL31095289 | 0.78 | ALDH1A1 (0.56) | LMNAKDM4EMAPTHSD17B10NPSR1 | |
| SCHEMBL28044046 | 0.78 | MTNR1B (0.56) | LMNAMTNR1BMAPTNPSR1NPC1 | |
| SCHEMBL130408 | 0.75 | ALDH1A1 (0.64) | LMNAKDM4EMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9344553 | 0.75 | LMNA (0.68) | SLC22A1ADRB2ADRB1LMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001046170-A1 | AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |