Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953478 | 0.95 | PDE4A (0.53) | PDE4AKCNH2GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL7953479 | 0.95 | PDE4A (0.53) | PDE4AKCNH2GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL7963060 | 0.91 | PDE4A (0.55) | PDE4AKCNH2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7953933 | 0.89 | PDE4A (0.53) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7955384 | 0.89 | PDE4A (0.44) | PDE4AKCNH2GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL7955386 | 0.89 | PDE4A (0.44) | PDE4AKCNH2GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL7951799 | 0.88 | PDE4A (0.57) | PDE4AKCNH2CYP2C9CYP3A4PDE4B | |
| SCHEMBL7961978 | 0.88 | PDE4A (0.53) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7961980 | 0.88 | PDE4A (0.53) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7963486 | 0.85 | GRIN2B (0.50) | GRIN2BCYP2D6CYP2C9CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |