Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 12/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7954870 | 0.94 | GRIN2B (0.46) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7954726 | 0.94 | GRIN2B (0.46) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7966046 | 0.90 | TSHR (0.47) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7960495 | 0.85 | PDE4A (0.54) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7954789 | 0.83 | ALDH1A1 (0.48) | KDM4E | |
| SCHEMBL7963864 | 0.83 | ALDH1A1 (0.48) | KDM4E | |
| SCHEMBL7955344 | 0.82 | KDM5C (0.49) | KDM4E | |
| SCHEMBL7955384 | 0.82 | PDE4A (0.44) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7955386 | 0.82 | PDE4A (0.44) | GRIN2BSMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL7960307 | 0.81 | KDM4E (0.55) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |