SCHEMBL7960670

SCHEMBL7960670

N#CC(S)c1ccc(F)cc1F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.40
CES1 P23141 2/20 0.40
IDO1 P14902 1/20 0.38
TDO2 P48775 1/20 0.38
ALDH1A1 P00352 2/20 0.35
SLC6A2 P23975 2/20 0.31
CA3 P07451 1/20 0.31
CA6 P23280 1/20 0.31
CA5A P35218 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
CA5B Q9Y2D0 1/20 0.31
MC4R P32245 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31
TRPV4 Q9HBA0 1/20 0.31
ATM Q13315 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6913446 0.76 CES2 (0.47) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL8186328 0.76 IDO1 (0.41) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL24059349 0.76 CES2 (0.37) CES2CES1IDO1TDO2ALDH1A1
Hydrochloric Acid SCHEMBL28334143 0.74 IDO1 (0.44) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL28480587 0.73 CES2 (0.41) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL25947213 0.72 CES2 (0.43) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL18948896 0.72 CES2 (0.43) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL11074082 0.71 CES2 (0.39) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL1507857 0.71 IDO1 (0.51) CES2CES1IDO1TDO2ALDH1A1
SCHEMBL7952407 0.70 LMNA (0.46) IDO1TDO2ALDH1A1CA9TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6225346-B1 FOR THERAPY AND PROPHYLAXIS OF CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS ASSOCIATED WITH PARTICULAR TYROSINE KINASES BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES SUGEN, INC. 2001-05-01 US disclosed
US-5935993-A TYROSINE KINASE INHIBITORS; TREATMENT OF CELL GROWTH, CELL DIFFERENTIATION DISORDERS SUGEN, INC. (US) 1999-08-10 US disclosed
US-5891917-A MODULATING TYROSINE SIGNAL TRANSDUCTION TO PREVENT AND TREAT CELL PROLIFERATIVE DISORDERS OR CELL DIFFERENTIATION DISORDERS ASSOCIATED WITH PARTICULAR TYROSINE KINASES BY INHIBITING ONE OR MORE ABNORMAL TYROSINE KINASE ACTIVITIES SUGEN, INC. (US) 1999-04-06 US disclosed