Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM1 | P23921 | 1/20 | 0.39 |
| ▸ | RRM2 | P31350 | 1/20 | 0.39 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960810 | 1.00 | RRM1 (0.39) | RRM1RRM2RRM2BCISD1GRM4 | |
| SCHEMBL6461091 | 0.84 | RRM1 (0.39) | RRM1RRM2RRM2BCISD1GRM4 | |
| SCHEMBL29620961 | 0.80 | EGLN2 (0.41) | TLR7HSP90AA1HSP90AB1PLAUIDO1 | |
| SCHEMBL19356897 | 0.78 | PLAU (0.37) | AKT1PIM1TLR7HSP90AA1PLAU | |
| SCHEMBL4219337 | 0.78 | RAB9A (0.38) | HSP90AA1PLAUKDM1AKDM4EMAPT | |
| SCHEMBL14394979 | 0.78 | ADRA2A (0.37) | PLAUKDM1AKDM4EMAPTBLM | |
| SCHEMBL2472438 | 0.78 | PLAU (0.50) | PIM1PLAUKDM1AKDM4EMAPT | |
| SCHEMBL5222559 | 0.78 | ADRA2A (0.37) | PLAUKDM1AKDM4EMAPTBLM | |
| SCHEMBL6452469 | 0.78 | PLAU (0.37) | AKT1PIM1TLR7HSP90AA1PLAU | |
| SCHEMBL6599961 | 0.78 | RAB9A (0.38) | HSP90AA1PLAUKDM1AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303613-B1 | AS NITRIC OXIDE SYNTHASE INHIBITOR USEFUL IN THERAPY OR PROPHYLAXIS OF INFLAMMATORY DISEASE AND PAIN | ASTRAZENECA AB (SE) | 2001-10-16 | — | — | US | disclosed |
| EP-0973772-A1 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998045294-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-15 | — | — | WO | disclosed |