Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960963 | 1.00 | GPR119 (0.54) | GPR119TACR1PDE4BKMT2AMEN1 | |
| SCHEMBL7960960 | 1.00 | GPR119 (0.54) | GPR119TACR1PDE4BKMT2AMEN1 | |
| SCHEMBL14608927 | 0.87 | TACR1 (0.52) | GPR119TACR1PDE4BSTSUSP30 | |
| SCHEMBL7842833 | 0.86 | GPR119 (0.56) | GPR119TACR1PDE4BKMT2AMEN1 | |
| SCHEMBL7841659 | 0.86 | GPR119 (0.56) | GPR119TACR1PDE4BKMT2AMEN1 | |
| SCHEMBL7841657 | 0.86 | GPR119 (0.56) | GPR119TACR1PDE4BKMT2AMEN1 | |
| SCHEMBL528604 | 0.85 | GPR119 (0.55) | GPR119TACR1PDE4BKMT2AMEN1 | |
| SCHEMBL7974558 | 0.85 | TACR1 (0.48) | GPR119TACR1KMT2AMEN1STS | |
| SCHEMBL7974562 | 0.85 | TACR1 (0.48) | GPR119TACR1KMT2AMEN1STS | |
| SCHEMBL7974565 | 0.85 | TACR1 (0.48) | GPR119TACR1KMT2AMEN1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |