Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | YAP1 | P46937 | 3/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | KLK7 | P49862 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974558 | 1.00 | TACR1 (0.48) | TACR1GPR119JAK2JAK1YAP1 | |
| SCHEMBL7974562 | 1.00 | TACR1 (0.48) | TACR1GPR119JAK2JAK1YAP1 | |
| SCHEMBL8702039 | 0.87 | GPR119 (0.45) | TACR1GPR119JAK2JAK1STS | |
| SCHEMBL7960963 | 0.85 | GPR119 (0.54) | TACR1GPR119STSUSP30KMT2A | |
| SCHEMBL7960958 | 0.85 | GPR119 (0.54) | TACR1GPR119STSUSP30KMT2A | |
| SCHEMBL7960960 | 0.85 | GPR119 (0.54) | TACR1GPR119STSUSP30KMT2A | |
| SCHEMBL7845432 | 0.84 | ALDH1A1 (0.43) | KMT2AMEN1TP53MAPTLMNA | |
| SCHEMBL4874370 | 0.83 | JAK2 (0.46) | TACR1GPR119JAK2JAK1YAP1 | |
| SCHEMBL2807737 | 0.82 | BACE1 (0.45) | TACR1JAK2JAK1YAP1USP30 | |
| SCHEMBL2807739 | 0.82 | BACE1 (0.45) | TACR1JAK2JAK1YAP1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |